By Peter Gnadig, G. Honyek, K. F. Riley
This article is going to boost a scholars skill to use the legislation of physics to sensible occasions and difficulties that yield extra simply to intuitive perception than to advanced arithmetic. those difficulties, selected nearly completely from classical (non-quantum) physics, are posed in obtainable nontechnical language and require the coed to pick the ideal framework during which to research the placement. The ebook can be valuable to undergraduates getting ready for «general physics» papers. a few physics professors may even locate the more challenging questions hard. The mathematical must haves are minimum and don't transcend straightforward calculus. This exciting publication of physics difficulties will end up instructive, hard and enjoyable.
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Extra info for 200 Puzzling Physics Problems: With Hints and Solutions
We have previously shown that it is possible to restore function to a large percentage of mutant CBS proteins by truncating the C-terminal domain of CBS or by having specific missense mutations within this domain. More recently, we have found that chemical chaperones can also restore enzyme activity to mutant CBS proteins. The overall goal of this application is to modulate the activity of mutant CBS enzymes by chemical and genetic means. There are four specific aims. First, we will determine the mechanism by which chemical chaperones restore function to mutant CBS proteins.
Associate Professor; Internal Medicine; University of Iowa Iowa City, Ia 52242 Timing: Fiscal Year 2005; Project Start 01-MAY-1998; Project End 30-APR-2007 Summary: (provided by applicant): Modest elevations in plasma homocysteine are associated with an increased risk of atherosclerotic disease. Impaired endothelial vasodilator function appears to play an important role in progression and complications of atherosclerosis. Thus, homocysteine-induced endothelial dysfunction is a plausible mechanism for predisposition to atherosclerosis.
We have carried out extensive studies on these compartmentalized pathways in yeast, but little is known about the enzymes and their regulation in mammals. Using molecular tools made possible by the Human Genome Project, we are now able to study the mitochondrial pathway in humans and other mammals. The Specific Aims are to: (1) Clone and express a cDNA encoding the human mitochondrial C1-THF synthase; (2) Purify and characterize the human enzyme; (3) Examine the expression and nutritional regulation of mitochondrial C1-THF synthase in human and mouse; and (4) Determine whether mutations in mitochondrial C1-THF synthase are related to neural tube defects or homocysteinemia.
200 Puzzling Physics Problems: With Hints and Solutions by Peter Gnadig, G. Honyek, K. F. Riley