By Lokesh Bhattacharyya, Jeffrey S. Rohrer
This can be a entire resource of data at the program of ion chromatography (IC) within the research of pharmaceutical medicinal drugs and biologicals. This ebook, with individuals from academia, pharma, the biotech undefined, and device production, provides different views, adventure, and services of the concept leaders of IC in a finished demeanour. It explores strength IC purposes in numerous elements of product improvement and qc checking out. moreover, an appendix part supplies info on serious actual and chromatographic parameters concerning IC and data on present brands of IC platforms, columns, and different components.Content:
Chapter 1 Ion Chromatography—Principles and functions (pages 1–21): Lokesh Bhattacharyya
Chapter 2 Retention approaches in Ion?Exclusion Chromatography: a brand new standpoint (pages 23–47): Milko Novic and Paul R. Haddad
Chapter three Pulsed Electrochemical Detection in Ion Chromatography (pages 49–90): William R. Lacourse
Chapter four Suppressor layout and Detection for Ion Chromatography (pages 91–105): Kannan Srinivasan, Sheetal Bhardwaj, Rong Lin and Christopher Pohl
Chapter five Modelling and Optimization of Ion Chromatographic Separations of Pharmaceutically proper natural Ions (pages 107–133): Philip Zakaria, Greg Dicinoski, Melissa Hanna?Brown and Paul R. Haddad
Chapter 6 Ion Chromatography in Pharmaceutical Drug research (pages 135–157): Lokesh Bhattacharyya
Chapter 7 research for Impurities by means of Ion Chromatography (pages 159–174): Shreekant V. Karmarkar
Chapter eight Ion Chromatography research of Aminoglycoside Antibiotics (pages 175–192): Valoran P. Hanko and Jeffrey S. Rohrer
Chapter nine Use of Cation?Exchange Ion Chromatography within the research of prescribed drugs (pages 193–220): Christopher Pohl, Maria Rey and Rosanne Slingsby
Chapter eleven excessive functionality Ion Chromatographic research of Cholinergic Compounds: Carbachol and Bethanechol, and linked Degradation items (pages 237–245): David Trowbridge
Chapter 12 Ion Chromatographic research of prescription drugs for Authenticity and Adulteration (pages 247–257): David S. Jackson
Chapter thirteen Ion Chromatography of Drug Product Counter?Ions and different Ions in Drug items (pages 259–269): Brian M. De Borba and Jeffrey S. Rohrer
Chapter 14 pattern guidance recommendations in Ion Chromatography for Pharmaceutical functions (pages 271–283): Jay Gandhi
Chapter 15 Validation of Ion Chromatographic equipment (pages 285–308): Shreekant V. Karmarkar
Chapter sixteen Pharmacopeial functions of Ion Chromatography (pages 309–320): Ravi Ravichandran
Chapter 10 complete ways for dimension of energetic Pharmaceutical parts, Counter?Ions, and Excipients utilizing HPLC with Charged Aerosol Detection (pages 221–236): Christopher Crafts, Bruce Bailey, Paul Gamache, Xiaodong Liu and Ian Acworth
Chapter 17 Glycan research by way of excessive functionality Anion alternate Chromatography with Pulsed Amperometric Detection (pages 321–338): Lokesh Bhattacharyya
Chapter 18 Monosaccharide research of Glycoproteins through High?Performance Anion?Exchange Chromatography with Pulsed Amperometric Detection (pages 339–350): Jeffrey S. Rohrer
Chapter 19 Two?Dimensional Ion Chromatography for Simultaneous choice of Amino Acids and Carbohydrates (pages 351–364): Petr Jandik and Jun Cheng
Chapter 20 tracking Protein N?Glycosylation Consistency utilizing HPAEC?PAD (pages 365–377): Carl Grey
Chapter 21 Oligosaccharide research via High?Performance Anion?Exchange Chromatography Hyphenated to built-in Pulsed Amperometric Detection and On?Line Ion?Trap Mass Spectrometry (pages 379–391): Cees Bruggink
Chapter 22 functions of Ion Chromatography in organic Product Analyses (pages 393–421): Alfred V. Del Grosso and Brandon Duong
Chapter 23 excessive functionality Anion?Exchange Chromatography with Pulsed Amperometric Detection (HPAEC?PAD) research of GBS Glycoconjugate Vaccines: From Fermentation to ultimate Product (pages 423–434): Stefano Ricci, Barbara Fabbri, Sara Giannini, Silvia Bernardini, Marcello Morelli and Sandro D'Ascenzi
Chapter 24 balance reviews and Characterization of Meningococcal A, C, Y, and W135 Glycoconjugate Vaccine (pages 435–447): Valeria Carinci, Alberto Bernardini, Cristiana Campa, Claudia Magagnoli, Francesca Beccai and Sandro D'Ascenzi
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Extra info for Applications of Ion Chromatography for Pharmaceutical and Biological Products
Pathol. Pharmacol. 1888;24:247–260. 12. Zhang Y, Cremer PS. Interactions between macromolecules and ions: The Hofmeister series. Current Opinion Chem. Biol. 2006;10:658–663. 13. Wheaton RM, Bauman WC. Ion exclusion. Annals of the NY Acad. Sci. 1953;57: 159–176. 14. Harlow GA, Morman DH. Automatic Ion exclusion-partition chromatography of acids. Anal. Chem. 1964;36:2438–2442. 15. Morris J, Fritz, JS. Eluent modiﬁers for the liquid chromatographic separation of carboxylic acids using conductivity detection.
Combined with the decreased intensity of its back-repulsion into the interstitial eluent at the tailing edge of the analyte band, this produces both symmetrical peaks and increased retention times. 3, and in particular the fact that the detector signal remains at a constant level during the back-conversion to the water form, before a sharp transition point is reached. During this back-conversion of the column to the water form, when the ﬁrst water segment reaches the ﬁrst loaded pore, both the concentration gradient and the electrostatic repulsion act in the same direction to rapidly transfer the eluent components from the occluded liquid into the interstitial eluent phase.
J. Chromatogr. A 2004;1039:147–153. 8. Schiller M, von der Heydt H, Maerz F, Schmidt PC. Quantiﬁcation of sugars and organic acids in hygroscopic, pharmaceutical herbal dry extracts. J. Chromatogr. A 2002;968:101–111. 9. Yang L, Liu L, Olsen BA, Nussbaum MA. The determination of oxalic acid, oxamic acid, and oxamide in a drug substance by ion-exclusion chromatography. J. Pharm. Biomed. Anal. 2000;22:487–493. 10. Haddad PR, Jackson PE. Ion Chromatography: Principles and Applications, Amsterdam: Elsevier; 1990.
Applications of Ion Chromatography for Pharmaceutical and Biological Products by Lokesh Bhattacharyya, Jeffrey S. Rohrer